One-Pot Greenstrategy for the Synthesis of Poly-Hydroquinoline Derivatives and Molecular Docking Study
Rapid expansion of antimicrobial-resistant pathogens has intensified the demand for chemotypes that are both potent and environmentally sustainable. We describe a green one-pot strategy for constructing a small library of polyhydroquinoline derivatives (4a–4e) starting from 5-methyl-2-aminopyridine and aromatic aldehydes in ethanol under catalytic HCl. Antimicrobial activity was assessed by agar well diffusion against Staphylococcus aureus, Bacillus anthracis, Pseudomonas aeruginosa, Escherichia coli, Candida albicans and Aspergillus niger.