Since, ancient times, Different extracts from traditional medicinal plants have been tested to identify the source of the therapeutic effects. Calotropisgigantia R, Br. (leaf) extract made in Methanol, Petroleum ether contains different secondary metabolites (Phytochemicals) with biological activity that can be of therapeutic index. Preliminary Phytochemical screening of plant parts of and Calotropisgigantia R, Br.. It is interesting to note that the action of the extracts of Calotropisgigantia R, Br. is non-toxic. Phytochemical screening of the crude extracts revealed the presence of saponins, tannins, alkaloids, and other phytoconstituents which were reported during present investigation were cardiac glycosides, flavonoids, glycosides, steroids, terpens and tannins. The consequences of this work has clarified that many active bioconstituents of Calotropisgigantia R, Br. consist effective qualities in its tending action. Herbal medicines have been used from the earliest times to the present day.
