Aim & background: Bioidentical hormone replacement therapy has completely altered the therapeutic concerns of Endocrinologists and gynecologists. The case discussed below is a prime example of their success. Case description: A 46-year-old woman suffering from perimenopausal conditions presents in the clinic. Her vitals and hormone profile were not at optimum levels. Ultrasound shows proliferative endometrium and ovarian cysts. She had been described with BHRT, including Estradiol, Progesterone, testosterone, and melatonin. She had been monitored regularly on her follow-ups and gradually improved. She had an improved lifestyle, which positively affected her mental and physical health. Conclusion : Eventually, it is concluded from this case that bioidentical hormones would play an important role in regulating normal body functions, even rebuild it after the patient lose it due to the fall in her hormone level. Clinical significance: Hormones have a huge impact on mental health as well.