Proteins are building blocks. It is important organic substances required by an organism in tissues building and repair. Under extreme stress conditions, proteins have been known to act as the energy supplier in metabolic pathways and biochemical reactions. In the present investigation Protein is found maximum in gonads throughout summer season, increasing in rainy and minimum in winter season followed by mantle, hepatopancreas, Add. Muscle and gill i.e., Gonad> Mantle> Hepatopancreas> Add. muscle> Gill. Glycogen are important organic substances required by an organism in cellular process. Under extreme stress conditions, glycogen have been known to act as the energy supplier in metabolic pathways and biochemical reactions. In the present investigation glycogen is found maximum in gonads throughout summer season, increasing in rainy and minimum in winter season followed by mantle, hepatopancreas, Add. Muscle and gill i.e., Gonad> Mantle> Hepatopancreas> Add. muscle>Gill .