The aim of the present study was to evaluate the possible cardio protective potency of Dalbergia latifolia leave against 5-FU-induced cardiotoxicity and oxidative stress in Albino rats. The rats were divided into five groups. Rats in the normal group received saline daily for 8 days only. Rats in Disease control group received saline orally for 8 days, then I.P. injected with 5-FU (150 mg\kg B.W) on the 5th day. Rat in standard group receive Vit. E (100mg/kg) for 8 day and on the 5th day rats were administrated with the same previous dose of 5-FU. Rats in D L-treated group (low dose) were orally dosed with DL (250 mg\kg B.W\day) for 8 days, and on the 5th day rats were administrated with the same previous dose of 5-FU. Rats in DL-treated group (High dose) were orally dosed with DL (500 mg\kg B.W\day) for 8 days, and on the 5th day rats were administrated with the same previous dose of 5-FU. Result: 5-FU induced cardiotoxicity was assessed by a significant increase in serum concentrations of lipid profile(Total cholesrtol, triglyceride, LDL). 5-FU significantly decreased serum HDL, and a moderate elevation of cardiac MDA and decrease in SOD,GLUTATHIONE PEROXIDASE and CATALASE. The histopathological studies also showed that the plant extract significantly minimized the damage induced by 5-FU. Conclusion: DL has a significant effect on the protection of the heart against 5-FU-induced cardiotoxicity through maintaining the cardio protective and antioxidant activity.
