Hepatoprotective activity of premna serratifolia linn. on experimental liver damage in rats

The aqueous extract of Premna serratifolia Linn (Verbenaceae), was tested for hepatoprotective activity against carbon tetrachloride- and paracetamol-induced hepatotoxicity in rats. Premna serratifolia Linn (Verbenaceae), exhibited significant hepatoprotective activity by reducing carbon tetrachloride- and paracetamol-induced change in bio-chemical parameters that was evident by enzymatic examination. The plant extract may interfere with free-radical formation, which may conclude in hepatoprotective action. Acute toxicity studies revealed that the L [D.sub.50] value is more than the dose of 4 g/kg body wt.