Ethnoscience is a term to encompass studies describe local people's interaction with the natural surroundings. Ethnomedicine with no doubt remains the main revenue contributing to both orthodox and tradional medicine. In developing countries like the India, the use of plants as medicine plays an important role especially in providing affordable and accessible health care. A comprehensive study on documenting traditional medicinal practices way carried at Lowa Santoshpur, Dwanari, Purba Burdwan district in WestBengal, India and analyzed for the first time. However, studies to determine the use-value (UV) of these plants, the informant consensus factor (ICF), the frequency of citation (FC) and Relative Frequency of Citation (RFC) have been scarce; hence, this study was conducted. For most of the communities there is a little published data on ethnomedicinally important plants, so data was collected on survey basis. Few, a total of 64 medicine practices were described for treatment of 21 diseases. They were documented from 182 informants. Among the documented data herbs and leaves are the most utilized pant, dominant families were the Fabaceae. The highest ICF value was 0.955 for digestive system disorders. Based on UVs, the most commonly used ethnomedicinal plant species in the study area were Azadirachta indica (0.37). The highest RFC was recorded for Azadirachta indica (0.049). The present study showed the traditional treatment using medicinal plants is still widespread in the study area. This study will promote furthur phytochemical and pharmacalogical investigations and possibly lead to the development of new drugs.