We describe a 60 year old female developing dengue-associated macrophage activation syndrome. The condition was diagnosed according to the established criteria of the International Histiocyte Society and Application of H-score. Patient was full recovery with corticosteroid therapy. Macrophage activation syndrome in adult mimic severe sepsis, systemic inflammatory response syndrome, or multi organ dysfunction syndrome and lead to diagnostic difficulties. This report adds to the limited adult cases of dengue related macrophage activation syndrome in literature. This documentation is presented because of a rare manifestation of a common disease. The importance of diagnosis and appropriate treatment of this rare case will enlight in dengue related literature. The outbreak of dengue in West Bengal in 2016 will more complicated in future as secondary dengue.
