Hair Palmo-plantar hyperkeratosis is characterized by abnormal thickening and roughness of the skin on the palms and soles, often resulting from increased keratin production. This condition can be triggered by various factors, including vitamin A deficiency and chronic exposure to toxins such as arsenic. A 63-year-old male patient with a history of diabetes, hypertension, and schizophrenia developed eczema on his palms and soles, which progressively worsened post-vaccination. The homeopathic approach offers a holistic treatment method that addresses both the physical symptoms and underlying causes. This paper explores the effectiveness of homeopathy in managing hyperkeratosis, particularly in cases with complicating factors such as chronic illness and post-vaccination reactions.